Treatable traits: toward precision medicine of chronic airway diseases.
Identifieur interne : 001505 ( Main/Exploration ); précédent : 001504; suivant : 001506Treatable traits: toward precision medicine of chronic airway diseases.
Auteurs : Alvar Agusti [Espagne] ; Elisabeth Bel [Pays-Bas] ; Mike Thomas [Royaume-Uni] ; Claus Vogelmeier [Allemagne] ; Guy Brusselle [Pays-Bas] ; Stephen Holgate [Royaume-Uni] ; Marc Humbert [France] ; Paul Jones [Royaume-Uni] ; Peter G. Gibson [Australie] ; J Rgen Vestbo [Royaume-Uni] ; Richard Beasley [Nouvelle-Zélande] ; Ian D. Pavord [Royaume-Uni]Source :
- The European respiratory journal [ 1399-3003 ] ; 2016.
Descripteurs français
- KwdFr :
- Asthme (immunologie), Asthme (physiopathologie), Asthme (traitement médicamenteux), Broncho-pneumopathie chronique obstructive (immunologie), Broncho-pneumopathie chronique obstructive (physiopathologie), Broncho-pneumopathie chronique obstructive (traitement médicamenteux), Humains, Inflammation, Médecine individualisée (), Phénotype.
- MESH :
- immunologie : Asthme, Broncho-pneumopathie chronique obstructive.
- physiopathologie : Asthme, Broncho-pneumopathie chronique obstructive.
- traitement médicamenteux : Asthme, Broncho-pneumopathie chronique obstructive.
- Humains, Inflammation, Médecine individualisée, Phénotype.
English descriptors
- KwdEn :
- MESH :
- drug therapy : Asthma, Pulmonary Disease, Chronic Obstructive.
- immunology : Asthma, Pulmonary Disease, Chronic Obstructive.
- methods : Precision Medicine.
- physiopathology : Asthma, Pulmonary Disease, Chronic Obstructive.
- Humans, Inflammation, Phenotype.
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.
DOI: 10.1183/13993003.01359-2015
PubMed: 26828055
Affiliations:
- Allemagne, Australie, Espagne, France, Nouvelle-Zélande, Pays-Bas, Royaume-Uni
- Angleterre, Grand Londres, Grand Manchester, Hollande-Méridionale, Hollande-Septentrionale, Oxfordshire
- Amsterdam, Londres, Manchester, Oxford, Rotterdam
- Université d'Amsterdam, Université d'Oxford, Université de Londres
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Le document en format XML
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Service de Pneumologie, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris); INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud; Service de Pneumologie, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris); INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Paul" sort="Jones, Paul" uniqKey="Jones P" first="Paul" last="Jones">Paul Jones</name><affiliation wicri:level="4"><nlm:affiliation>St George's University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Gibson, Peter G" sort="Gibson, Peter G" uniqKey="Gibson P" first="Peter G" last="Gibson">Peter G. 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University of Barcelona, Barcelona and CIBER Enfermedades Respiratorias (CIBERES), Spain Alvar.Agusti@clinic.ub.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Respiratory Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona and CIBER Enfermedades Respiratorias (CIBERES)</wicri:regionArea><wicri:noRegion>Barcelona and CIBER Enfermedades Respiratorias (CIBERES)</wicri:noRegion></affiliation></author><author><name sortKey="Bel, Elisabeth" sort="Bel, Elisabeth" uniqKey="Bel E" first="Elisabeth" last="Bel">Elisabeth Bel</name><affiliation wicri:level="4"><nlm:affiliation>Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Thomas, Mike" sort="Thomas, Mike" uniqKey="Thomas M" first="Mike" last="Thomas">Mike Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Primary Care and Population Sciences, University of Southampton, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Primary Care and Population Sciences, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Vogelmeier, Claus" sort="Vogelmeier, Claus" uniqKey="Vogelmeier C" first="Claus" last="Vogelmeier">Claus Vogelmeier</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, and Member of the German Center for Lung Research (DZL), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, and Member of the German Center for Lung Research (DZL)</wicri:regionArea><wicri:noRegion>and Member of the German Center for Lung Research (DZL)</wicri:noRegion><wicri:noRegion>and Member of the German Center for Lung Research (DZL)</wicri:noRegion><wicri:noRegion>and Member of the German Center for Lung Research (DZL)</wicri:noRegion></affiliation></author><author><name sortKey="Brusselle, Guy" sort="Brusselle, Guy" uniqKey="Brusselle G" first="Guy" last="Brusselle">Guy Brusselle</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Depts of Epidemiology and Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Depts of Epidemiology and Respiratory Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Holgate, Stephen" sort="Holgate, Stephen" uniqKey="Holgate S" first="Stephen" last="Holgate">Stephen Holgate</name><affiliation wicri:level="1"><nlm:affiliation>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Sud; Service de Pneumologie, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris); INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud; Service de Pneumologie, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris); INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Paul" sort="Jones, Paul" uniqKey="Jones P" first="Paul" last="Jones">Paul Jones</name><affiliation wicri:level="4"><nlm:affiliation>St George's University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Gibson, Peter G" sort="Gibson, Peter G" uniqKey="Gibson P" first="Peter G" last="Gibson">Peter G. Gibson</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, and Priority Research Centre for Asthma and Respiratory Disease, The University of Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, and Priority Research Centre for Asthma and Respiratory Disease, The University of Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Vestbo, J Rgen" sort="Vestbo, J Rgen" uniqKey="Vestbo J" first="J Rgen" last="Vestbo">J Rgen Vestbo</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Respiratory Medicine and Allergy, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Respiratory Medicine and Allergy, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Beasley, Richard" sort="Beasley, Richard" uniqKey="Beasley R" first="Richard" last="Beasley">Richard Beasley</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Institute of New Zealand, Wellington, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Medical Research Institute of New Zealand, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name><affiliation wicri:level="4"><nlm:affiliation>Respiratory Medicine Unit, NDM Research Building, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Medicine Unit, NDM Research Building, Nuffield Dept of Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">The European respiratory journal</title><idno type="eISSN">1399-3003</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asthma (drug therapy)</term><term>Asthma (immunology)</term><term>Asthma (physiopathology)</term><term>Humans</term><term>Inflammation</term><term>Phenotype</term><term>Precision Medicine (methods)</term><term>Pulmonary Disease, Chronic Obstructive (drug therapy)</term><term>Pulmonary Disease, Chronic Obstructive (immunology)</term><term>Pulmonary Disease, Chronic Obstructive (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Asthme (immunologie)</term><term>Asthme (physiopathologie)</term><term>Asthme (traitement médicamenteux)</term><term>Broncho-pneumopathie chronique obstructive (immunologie)</term><term>Broncho-pneumopathie chronique obstructive (physiopathologie)</term><term>Broncho-pneumopathie chronique obstructive (traitement médicamenteux)</term><term>Humains</term><term>Inflammation</term><term>Médecine individualisée ()</term><term>Phénotype</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Asthma</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Precision Medicine</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Inflammation</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Inflammation</term><term>Médecine individualisée</term><term>Phénotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Grand Manchester</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Oxfordshire</li></region><settlement><li>Amsterdam</li><li>Londres</li><li>Manchester</li><li>Oxford</li><li>Rotterdam</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université d'Oxford</li><li>Université de Londres</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Agusti, Alvar" sort="Agusti, Alvar" uniqKey="Agusti A" first="Alvar" last="Agusti">Alvar Agusti</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Bel, Elisabeth" sort="Bel, Elisabeth" uniqKey="Bel E" first="Elisabeth" last="Bel">Elisabeth Bel</name></region><name sortKey="Brusselle, Guy" sort="Brusselle, Guy" uniqKey="Brusselle G" first="Guy" last="Brusselle">Guy Brusselle</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Thomas, Mike" sort="Thomas, Mike" uniqKey="Thomas M" first="Mike" last="Thomas">Mike Thomas</name></noRegion><name sortKey="Holgate, Stephen" sort="Holgate, Stephen" uniqKey="Holgate S" first="Stephen" last="Holgate">Stephen Holgate</name><name sortKey="Jones, Paul" sort="Jones, Paul" uniqKey="Jones P" first="Paul" last="Jones">Paul Jones</name><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name><name sortKey="Vestbo, J Rgen" sort="Vestbo, J Rgen" uniqKey="Vestbo J" first="J Rgen" last="Vestbo">J Rgen Vestbo</name></country><country name="Allemagne"><noRegion><name sortKey="Vogelmeier, Claus" sort="Vogelmeier, Claus" uniqKey="Vogelmeier C" first="Claus" last="Vogelmeier">Claus Vogelmeier</name></noRegion></country><country name="France"><noRegion><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Gibson, Peter G" sort="Gibson, Peter G" uniqKey="Gibson P" first="Peter G" last="Gibson">Peter G. Gibson</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Beasley, Richard" sort="Beasley, Richard" uniqKey="Beasley R" first="Richard" last="Beasley">Richard Beasley</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26828055" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |